Topical treatments for pain

05 Jul.,2023

 

  1. Argoff CE: New analgesics for neuropathic pain: the lidocaine patch. Clin J Pain 2000, Suppl 16:S62-S65.

  2. Argoff CE: Targeted topical peripheral analgesics in the management of pain. Curr Pain Headache Rep 2002, 7:34–38.

  3. Galer BS: Topical medications. In Bonica’s Management of Pain. Edited by Loeser JD. Philadelphia: Lippincott Williams & Wilkins; 2001:1736–1741. This effectively reviews the subject.

  4. Gammaitoni AR, Alvarez NA: 24-hour application of the lidocaine patch 5% for 3 consecutive days is safe and well tolerated in healthy adult men and women [Abstract PO6.20]. Presented at the 54th Annual American Academy of Neurology Meeting. Denver: April 13–20, 2002.

  5. Argoff C, Nicholson B, Moskowitz M, et al.: Effectiveness of lidocaine patch 5% (Lidoderm®) in the treatment of low back pain. Presented at the 10th World Congress on Pain. San Diego: August 17–22, 2002.

  6. Watson CP: Topical capsaicin as an adjuvant analgesic. J Pain Symptom Manage 1994, 9:425–433.

  7. Gammaitoni AR, Davis MW: Pharmacokinetics and to lerability of lidocaine 5% patch with extended dosing. Ann Pharmacother 2002, 36:236–240.

  8. Ness TJ, Jones L, Smith H: Use of compounded topical analgesics: results of an Internet survey. Reg Anesth Pain Med 2002, 27:309–312.

  9. Sawynok J: Topical and peripherally acting analgesics. Pharmacol Rev 2003, 55:1–20.

  10. Robbins W: Clinical applications of capsaicinoids. Clin J Pain 2000, Suppl 16:S86-S89. This review examines the potential of these agents as topical analgesics.

  11. Rowbotham MC: Topical analgesic agents. In Pharmacologic Approaches to the Treatment of Chronic Pain: New Concepts and Critical Issues. Edited by Fields HL, Liebeskind JC. Seattle: IASP Press; 1994:211–227.

  12. Cashman JN: The mechanism of action of NSAIDs in analgesia. Drugs 1996, 52(suppl 5):13–23.

  13. Yesilyurt O, Dogrul A, Gul H, et al.: Topical cannabinoid enhances topical morphine antinociception. Pain 2003, 105:303–308.

  14. Sawynok J, Esser MJ, Reid AR: Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J Psychiatry Neurosci 2001, 26:21–29. This exciting review suggests some of the less commonly reported mechanisms of antidepressants as analgesics.

  15. Gerner P, Kao G, Srinivasa V, et al.: Topical amitriptyline in health volunteers. Reg Anesth Pain Med 2003, 28:289–293.

  16. Physicians Desk Reference, edn 55. Montvale, NJ: Medical Economics Company; 2002.

  17. Rowbotham MC, Davies PS, Verkempinck, et al.: Lidocaine patch: double-blind, controlled study of a new treatment method for post-herpetic neuralgia. Pain 1996, 65:39–44.

  18. Galer BS, Rowbotham MC, Perander J, et al.: Topical lidocaine patch relieves post-herpetic neuralgia more effectively than vehicle patch: results of an enriched enrollment study. Pain 1999, 80:533–538.

  19. Katz NP, Davis MW, Dworkin RH: Topical lidocaine patch produces a significant improvement in mean pain scores and pain relief in treated PHN patients: results of a multicenter open-label trial. J Pain 2001, 2:9–18.

  20. Meier T, Wasner G, Faust M, et al.: Efficacy of lidocaine patch 5% in the treatment of focal peripheral neuropathic pain syndromes: a randomized, double-blind, placebo-controlled study. Pain 2003, 106:151–158.

  21. Devers A, Galer BS: Topical lidocaine patch relieves a variety of neuropathic pain conditions: an open-label study. Clin J Pain 2000, 16:205–208.

  22. Data on file. Endo Pharmaceuticals, Inc. Chadds Ford, PA.

  23. Hart-Gouleau S, Gammaitoni A, Galer BS, et al.: Open-label study of the effectiveness and safety of the lidocaine patch 5% (Lidoderm®) in patients with painful diabetic neuropathy. Presented at the 10th World Congress on Pain. San Diego: August 17–22, 2002.

  24. Galer BS, Jensen MP: Development and preliminary validation of a pain measure specific to neuropathic pain: the Neuropathic Pain Scale. Neurology 1997, 48:332–338.

  25. Barbano RL, Herrmann DN, Hart-Gouleau S, et al.: Effectiveness, tolerability, and impact on quality of life of lidocaine patch 5% in diabetic polyneuropathy. Arch Neurol, accepted for publication.

  26. Galer BS, Jensen MP, Ma T, et al.: The lidocaine patch 5% effectively treats all neuropathic pain qualities: results of a randomized, double-blind, vehicle-controlled, 3-week efficacy study with use of the Neuropathic Pain Scale. Clin J Pain 2002, 18:297–301.

  27. Lycka BA, Watson CP, Nevin K, et al.: EMLA® cream for the treatment of pain caused by post-herpetic neuralgia: a double-blind, placebo-controlled study [Abstract]. Proceedings of the 1996 Annual Meeting of the American Pain Society 1996, A111.

  28. Attal N, Brasseur L, Chauvin M, et al.: Effects of single and repeated applications of a eutectic mixture of local anesthetics (EMLA®) cream on spontaneous and evoked pain in postherpetic neuralgia. Pain 1999, 81:203–209.

  29. Litman SJ, Vitkun SA, Poppers PJ: Use of EMLA® cream in the treatment of post-herpetic neuralgia. J Clin Anesth 1996, 8:54–57.

  30. Lynch ME, Clark AJ, Sawynok J: A pilot study examining topical amitriptyline, ketamine, and a combination of both in the treatment of neuropathic pain. Clin J Pain 2003, 19:323–328.

  31. Quan D, Wellish M, Gilden DH: Topical ketamine treatment of postherpetic neuralgia. Neurology 2003, 60:1391–1392.

  32. Greenway FL, Frome BM, Engels TM, et al.: Temporary relief of post-herpetic neuralgia pain with topical geranium oil. Am J Med 2003, 115:586–587.

  33. Rains C, Bryson HM: Topical capsaicin: a review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy, and osteoarthritis. Drugs Aging 1995, 7:317–328.

  34. Robbins WR, Staats PS, Levine J, et al.: Treatment of intractable pain with topical large-dose capsaicin: preliminary report. Anesth Analg 1998, 86:579–583.

  35. McCleane G: Topical application of doxepin hydrochloride, capsaicin, and a combination of both produces analgesia in chronic neuropathic pain: a randomized, double-blind, placebo-controlled study. Br J Clin Pharmacol 2000, 49:574–579.

  36. Marten M: Efficacy and tolerability of a topical NSAID patch (local action transcutaneous flurbiprofen) and oral diclofenac in the treatment of soft-tissue rheumatism. Clin Rheumatol 1997, 16:25–31.

  37. Galer BS, Rowbotham MC, Perander J, et al.: Topical diclofenac patch significantly reduces pain associated with minor sports injuries: results of a randomized, double-blind, placebo-controlled, multicenter study. J Pain Symptom Manage 2000, 19:287–294.

  38. Jenoure P, Segesser B, Luhti U, et al.: A trial with diclofenac HEP plaster as topical treatment in minor sports injuries. Drugs Exp Clin Res 1993, 19:125–131.

  39. Bruhlmann P, Michel BA: Topical diclofenac patch in patients with knee osteoarthritis: a randomized, double-blind, controlled clinical trial. Clin Exp Rheumatol 2003, 21:193–198.

  40. Campbell J, Dunn T: Evaluation of topical ibuprofen cream in the treatment of acute ankle sprains. J Accidental Emerg Med 1994, 11:178–182.

  41. Airaksinen O, Venalainen J, Pietilainen T: Ketoprofen 2.5% gel versus placebo gel in the treatment of acute soft tissue injuries. Int J Clin Pharmacol Ther Toxicol 1993, 31:561–563.

  42. Machen J, Whitefield M: Efficacy of a proprietary ibuprofen gel in soft tissue injuries: a randomized, double-blind, placebo-controlled study. Intl J Clin Prac 2002, 56:102–106.

  43. Whitefield M, O’Kane CJ, Anderson S: Comparative efficacy of a proprietary topical ibuprofen gel and oral ibuprofen in acute soft tissue injuries: a randomized, double-blind study. J Clin Pharm Ther 2002, 27:409–417.

  44. Ottillinger B, Gomor B, Michel BA, et al.: Efficacy and safety of eltenac gel in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 2001, 9:273–280.

  45. Sandelin J, Harilainen A, Crone H, et al.: Local NSAID gel (eltenac) in the treatment of osteoarthritis of the knee: a doubleblind study comparing eltenac with oral diclofenac and placebo gel. Scand J Rheumatol 1997, 26:287–292.

  46. Dreiser RL, Tisne-Camus M: DHEP plasters as a topical treatment of knee osteoarthritis: a double-blind, placebo-controlled study. Drugs Exp Clin Res 1993, 19:107–115.

  47. Galeazzi M, Marcolongo R: A placebo-controlled study of the efficacy and tolerability of a nonsteroidal anti-inflammatory drug, DHEP plaster, in inflammatory peri- and extra-articular rheumatological diseases. Drugs Exp Clin Res 1993, 19:107–115.

  48. Gallachia G, Marcolongo R: Pharmacokinetics of diclofenac hydroxyethylpyrrolidine (DHEP) plasters in patients with monolateral knee joint effusion. Drugs Exp Clin Res 1993, 19:95–97.

  49. Winocur E, Gavish A, Halachmi M, et al.: Topical application of capsaicin for the treatment of localized pain in the temporomandibular joint area. J Orofac Pain 2000, 14:31–36.

  50. Cohen M, Wolfe R, Mai T, et al.: A randomized, double-blind, placebo-controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. J Rheumatol 2003, 30:523–528.

  51. Keitel W, Frerick H, Kuhn U, et al.: Capsicum pain plaster in chronic non-specific low back pain. Arzneimittelforschung 2001, 51:896–903.

  52. Lipman AG, Dalpiaz AS, London SP: Topical lidocaine patch therapy for myofascial pain [Abstract 782]. Presented at the Annual Scientific Meeting of the American Pain Society. Baltimore: March 14–17, 2002.

  53. Briggs M, Nelson EA: Topical agents or dressings for pain in venous leg ulcers. Cochrane Database Syst Rev 2003, 1:CD001177.

  54. Flock P: Pilot study to determine the effectiveness of diamorphine gel to control pressure ulcer pain. J Pain Symptom Manage 2003, 25:547–554.

  55. Zeppetella G, Ribeiro PJ: Analgesic efficacy of morphine applied topically to painful ulcers. J Pain Symptom Manage 2003, 25:555–558.

  56. Fassoulaki A, Sarantopoulos C, Melemeni A, et al.: EMLA reduces acute and chronic pain after breast surgery for cancer. Reg Anesth Pain Med 2000, 25:350–355.

  57. Cerchietti LC, Navigante AH, Bonomi MR, et al.: Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. Cancer 2002, 95:2230–2236.

  58. Slatkin NE, Rhiner M: Topical ketamine in the treatment of mucositis pain. Pain Med 2003, 4:298–303.

  59. Galeotti N, DeCesare Mannelli L, Mazzanti G, et al.: Menthol: a natural analgesic compound. Neurosci Lett 2002, 322:145–148.

  60. Sandroni P: Central neuropathic itch: a new treatment option? Neurology 2002, 59:778–779.

  61. Backonja M, Malan P, Brady S, et al.: One-hour high concentration trans-capsaicin applications provide durable pain relief in initial and repeat treatment of postherpetic neuralgia. Presented at the 2004 Annual Scientific Meeting of the American Academy of Neurology. San Francisco: April 24–May 1, 2004.

  62. Simpson D, Brown S, Sampson J, et al.: A single application of high-concentration trans-capsaicin leads to 12 weeks of pain relief in HIV-associated distal symmetrical polyneuropathy: results of an open label trail. Presented at the 2004 Annual Scientific Meeting of the American Academy of Neurology. San Francisco: April 24–May 1, 2004.

  63. Lockhart E: Topical combination of amitriptyiline and ketamine for post herpetic neuralgia. J Pain 2004, 3(suppl 1):82.

  64. Bernstein J, Phillips S, Group T: A new topical medication for the adjunctive relief of painful diabetic neuropathy and postherpetic neuralgia. J Pain 2004, 3(suppl 1):82.

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